" /> Firicabtagene Autoleucel - CISMeF





Preferred Label : Firicabtagene Autoleucel;

NCIt synonyms : Autologous Anti-CD22-CAR m971-BBz T-cells CRG-022; Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes CRG-022;

NCIt definition : A preparation of autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of an anti-CD22 single chain variable fragment (scFv) derived from the monoclonal antibody (moAb) 971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration, firicabtagene autoleucel binds to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells. m971 binds to a membrane proximal epitope on CD22 and has a higher binding affinity compared to other anti-CD22 moAb.;

UNII : 4BEJ6K4DQ9;

Molecule name : CRG-022; CRG 022;

NCI Metathesaurus CUI : CL1922255;

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31/05/2025


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