NCIt definition : A preparation of autologous human T-lymphocytes transduced with a recombinant lentiviral
vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting
of an anti-CD22 single chain variable fragment (scFv) derived from the monoclonal
antibody (moAb) 971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to
the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating
and antineoplastic activities. Upon administration, firicabtagene autoleucel binds
to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells
are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed
on malignant B-cells. m971 binds to a membrane proximal epitope on CD22 and has a
higher binding affinity compared to other anti-CD22 moAb.;