Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120

Preferred Label : Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120;

NCIt synonyms : Autologous CD19/CD22 CAR T Cells; Autologous CD19/CD22 Chimeric Antigen Receptor T Cells; Autologous CD19/CD22 CAR T-cells; Autologous Anti-CD19/CD22 CAR-T Cells;

NCIt related terms : CD19/CD22 CAR-T; CD19/CD22 Bispecific CAR-T;

NCIt definition : A preparation of autologous human T-lymphocytes engineered to express a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains targeting the tumor-associated antigens (TAAs) CD19 and CD22 and fused to one or more co-stimulatory TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD19/CD22 CAR T-cells CT120 bind to CD19 and CD22 on the surface of, and induce selective toxicity against, tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are overexpressed on malignant B-cells.;

Molecule name : CT 120; CT-120;

NCI Metathesaurus CUI : CL540702;

Details

Origin ID

C142834;

UMLS CUI

C5575850;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Cell Receptor CD22 [NCIt concept]
- B-Lymphocyte Antigen CD19 [NCIt concept]

Keyword's position in hierarchy(ies) :

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