Preferred Label : Anti-CD22 ADC TRPH-222;
NCIt synonyms : Anti-CD22 Antibody-drug Conjugate TRPH-222; Anti-CD22-4AP ADC TRPH-222;
NCIt related terms : TRPH-222;
NCIt definition : An antibody-drug conjugate (ADC) composed of an anti-CD22 humanized monoclonal antibody
site-specifically conjugated to, via formylglycine (FG) residues and a protease insensitive
4AP linker, a cytotoxic microtubule-targeting maytansinoid payload, with potential
antineoplastic activity. Upon administration, the monoclonal antibody moiety of TRPH-222
binds to B-cell-specific CD22 receptors and is rapidly internalized, thereby delivering
the payload intracellularly. Upon proteolytic cleavage, the maytansinoid payload binds
to tubulin, disrupting microtubule assembly/disassembly dynamics, inhibiting both
cell division and tumor cell proliferation. CD22, a cell surface sialoglycoprotein,
is expressed on mature B-cells and on most malignant B-cells. The site specific and
stable conjugation to the payload allows for a higher drug-to-antibody ratio (DAR)
and an enhanced therapeutic index.;
UNII : 00NT1ETN9K;
Molecule name : TRPH-222; CAT-02-106; TRPH 222;
NCI Metathesaurus CUI : CL935995;
Origin ID : C156882;
UMLS CUI : C4745143;
Semantic type(s)
- concept_is_in_subset
- has_target
