Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells - CISMeF
Autologous Anti-PD-L1-armored Anti-CD22 CAR T CellsNCIt concept
Preferred Label : Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells;
NCIt synonyms : SL22P Autologous CAR-T Cells; CD22 (aPD-L1) CAR-T Cells; Autologous aPD-L1-armored CD22-targeting CAR T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to
express a chimeric antigen receptor (CAR) specific for the human tumor-associated
antigen (TAA) CD22 and carrying a single-chain variable fragment (scFv) of a monoclonal
antibody targeting the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1;
cluster of differentiation 274; CD274), with potential immunomodulatory and antineoplastic
activities. Upon infusion, the autologous anti-PD-L1-armored anti-CD22 CAR T cells
target and bind to CD22-expressing tumor cells, thereby inducing selective toxicity
in CD22-expressing tumor cells. The scFv moiety binds to PD-L1, blocking the binding
of PD-L1 to its receptor programmed cell death 1 (PD-1; cluster of differentiation
279; CD279), thereby preventing PD-1 activation on T-lymphocytes. This reverses T-cell
inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte
(CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1
is overexpressed by many human cancer cell types and plays a key role in the downregulation
of the immune system and tumor evasion from host immunity. PD-1, found on activated
T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion
and prevents tumor cell lysis. CD22, a cell surface glycoprotein, is expressed on
mature B-cells and on most malignant B-cells.;
Molecule name : Autologous aPD-L1-Armored Anti-CD22 CAR T Cells; SL22P CAR T Cells;