Preferred Label : Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO;
NCIt synonyms : Anti-CD19/CD20/CD22 CAR T Cells LCAR-AIO; Tri-specific CD19xCD20xCD22 CAR-T Cells LCAR-AIO; Anti-CD19/CD20/CD22 CAR T-cells LCAR-AIO;
NCIt definition : A preparation of human T-lymphocytes that have been genetically modified and transduced
with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the
tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22,
with potential immunostimulating and antineoplastic activities. Upon administration,
the anti-CD19/anti-CD20/anti-CD22 CAR-T cells LCAR-AIO target and bind to CD19, CD20
and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity
in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic
malignancies.;
Molecule name : LCAR-AIO;
NCI Metathesaurus CUI : CL1792017;
Origin ID : C187129;
UMLS CUI : C5706376;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
