" /> B-Lymphocyte Antigen CD20 - CISMeF





Preferred Label : B-Lymphocyte Antigen CD20;

NCIt synonyms : CD20 Antigen; CD20 Receptor; Leu-16; B-Lymphocyte Surface Antigen B1; MS4A1; Membrane-Spanning 4-Domains Subfamily A Member 1; Bp35; B1;

NCIt related terms : CD20;

NCIt definition : B-lymphocyte antigen CD20 (297 aa, 33 kDa) is encoded by the human MS4A1 gene. This protein plays a role in both the activation and proliferation of B-cells.;

NCIt note : Expressed during B-cell ontogeny (early pre-B-cell to plasma cell) by human CD20 Gene (MS4A Family), 297-aa 33-kDa CD20 Antigen is a phosphorylated cell surface integral membrane protein shown to participate in B-cell proliferation, development, and differentiation into plasma cells. MS4A family proteins share structural similarity, sequence homology, and unique expression patterns among hematopoietic cells and nonlymphoid tissues. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. CD20 may be involved in regulation of B-cell activation and may be regulated by protein kinases.;

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13/05/2024


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