Preferred Label : Anti-CD20 Antibody-drug Conjugate MRG001;
NCIt synonyms : ADC MRG001; Anti-CD20 ADC MRG001; Anti-CD20/MMAE ADC MRG001;
NCIt definition : An antibody-drug conjugate (ADC) composed of a chimeric anti-CD20 monoclonal antibody
conjugated via a valine citrulline linker to monomethyl auristatin E (MMAE), an auristatin
derivative and a potent microtubule disrupting agent, with potential antineoplastic
activity. Upon administration of anti-CD20 ADC MRG001, the monoclonal antibody moiety
of MRG001 targets and binds to CD20 on the surfaces of tumor B-cells and is rapidly
internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage,
MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint
arrest and apoptosis in CD20-expressing tumor cells. CD20 is a non-glycosylated cell
surface phosphoprotein which is exclusively expressed on B-cells during most stages
of B-cell development. It is often overexpressed in B-cell malignancies.;
Molecule name : MRG 001; MRG-001;
NCI Metathesaurus CUI : CL1778251;
Origin ID : C185870;
UMLS CUI : C5667037;
Semantic type(s)
- concept_is_in_subset
- has_target
