Ocrelizumab - CISMeF

Preferred Label : Ocrelizumab;

NCIt synonyms : rhuMAb 2H7;

NCIt definition : A Fc-modified, humanized monoclonal antibody directed against the B-cell CD20 cell surface antigen, with immunosuppressive activity. Ocrelizumab binds to CD20 on the surfaces of B-cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B-cells overexpressing CD20. The CD20 antigen, a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel, is found on over 90% of B-cells, B-cell lymphomas, and other lymphoid tumor cells of B-cell origin; it plays an important role in B-cell functioning.;

UNII : A10SJL62JY;

CAS number : 637334-45-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 637334-45-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PRO-70769; PR070769; RO4964913;

Details

Origin ID

C66250;

UMLS CUI

C1882138;

Automatic exact mappings (from CISMeF team)
- Ocrelizumab [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Ocrelizumab (substance) [SNOMED CT concept]
- ocrelizumab [MeSH concept]
- ocrelizumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing ocrelizumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ocrelizumab (substance) [SNOMED CT concept]
- Product containing ocrelizumab (medicinal product) [SNOMED CT concept]
- ocrelizumab [ATC Code]
- ocrelizumab [MeSH concept]
- ocrelizumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- ocrelizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD20 [NCIt concept]

Keyword's position in hierarchy(ies) :

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