" /> Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369 - CISMeF





Preferred Label : Autologous Anti-CD79a/anti-CD20 CAR T-cells bbT369;

NCIt synonyms : Autologous Anti-CD20/CD79a CAR T-cells bbT369;

NCIt definition : A preparation of genetically modified autologous T-lymphocytes that are transduced with a single lentiviral vector (LVV) to express chimeric antigen receptors (CARs) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and the B-cell antigen receptor complex-associated protein alpha chain (CD79a), and transfected with an mRNA encoding the Casitas B-lineage lymphoma proto-oncogene-b (CBLB)-targeting megaTAL enzyme to edit the CBLB gene, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD20/CD79a CAR-T cells bbT369 target and bind to CD20- and CD79a-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD20 and CD79a are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD20 and CD79a may prevent tumor cell antigen escape and relapse, and may increase anti-tumor activity. The removal of CBLB, an E3 ubiquitin ligase and a negative regulator of T-cell function, will increase T-cell expansion and activation.;

Molecule name : bbT-369; bbT 369;

NCI Metathesaurus CUI : CL1778585;

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12/05/2024


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