" /> Obinutuzumab - CISMeF





Preferred Label : Obinutuzumab;

NCIt synonyms : Anti-CD20 Monoclonal Antibody R7159; huMAB(CD20); Afutuzumab;

NCIt definition : A glycoengineered, humanized IgG1 monoclonal antibody with potential antineoplastic activity. Obinutuzumab, a third generation type II anti-CD20 antibody, selectivity binds to the extracellular domain of the human CD20 antigen on malignant human B cells. The Fc region carbohydrates of the antibody, enriched in bisected non-fucosylated glycosylation variants, contribute to its higher binding affinity for human FcgammaRIII receptors compared to non-glycoengineered antibodies, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and caspase-independent apoptosis. In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells.;

UNII : O43472U9X8;

CAS number : 949142-50-1;

Drug name : Gazyva;

Molecule name : R-7159; RO 5072759; GA-101; RO-5072759; GA 101; R 7159;

Codes from synonyms : 361;

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31/07/2025


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