" /> Autologous Anti-CD19/CD20 Bispecific CAR-T Cells IMPT-314 - CISMeF





Preferred Label : Autologous Anti-CD19/CD20 Bispecific CAR-T Cells IMPT-314;

NCIt synonyms : Autologous Anti-CD19/CD20 OR-gate CAR T-cells IMPT-314; Autologous Anti-CD19/CD20 CAR T Cells IMPT-314;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD19/CD20 bispecific CAR-T cells IMPT-314 target and bind to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse.;

Molecule name : IMPT-314; IMPT 314;

NCI Metathesaurus CUI : CL1906561;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.