NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a lentiviral
vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated
antigen (TAA) cluster of differentiation 20 (CD20) and coupled to the co-stimulatory
signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of
the T-cell receptor (TCR)/CD3 complex (CD3zeta), with potential immunostimulating
and antineoplastic activities. Upon administration, autologous anti-CD20CAR-CD28-4-1BB-CD3zeta
T-lymphocytes MB-106 specifically recognize and kill CD20-expressing tumor cells.
The CD20 antigen, a non-glycosylated B-cell specific surface phosphoprotein that plays
a role in the differentiation of B-cells into plasma cells, is overexpressed in B-cell
lineage malignancies and certain melanoma cell subpopulations.;