NCIt synonyms : Autologous Anti-CD19/Anti-CD20 CAR T Cells KITE-363; Autologous CD19/CD20-targeting CAR T-cells KITE-363;
NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen
receptor (CAR) specific for the two tumor-associated antigens (TAAs) cluster of differentiation
19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities.
Upon administration, the autologous anti-CD19/CD20 CAR-T cells KITE-363 target and
bind to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity in
tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface
antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20
may prevent tumor cell antigen escape and relapse.;