NCIt definition : A trifunctional bispecific monoclonal antibody with potential antineoplastic activity.
FBTA05 contains two antigen-recognition sites: one for human CD3, a T cell surface
antigen; and one for human CD20, a tumor-associated antigen that is exclusively expressed
on B cells during most stages of B cell development and often overexpressed in B-cell
malignancies. In addition, the modified Fc portion of this antibody binds Fc receptors
on antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs).
FBTA05 brings T cells, CD20-expressing tumor B-cells and APCs together into tricellular
complexes, which may result in a potent cytotoxic T-lymphocyte (CTL) response against
CD20-expressing tumor B-cells. Fc-mediated binding of APCs in the tricellular complex
potentiates CD20 antigen presentation to T cells and the activation of anti-tumor
cytotoxic T cells.;
Semantic type(s)