Preferred Label : Anti-CD20/Anti-CD3/Anti-CD8 Trispecific Antibody AZD5492;
NCIt synonyms : T-cell Engager AZD5492; TCE AZD5492; Triple-specific Antibody AZD5492; CD8/TCR-based CD20-targeting T-cell Engaging Antibody AZD5492; T-cell Engaging Antibody AZD5492;
NCIt definition : A trispecific immunoglobulin G (IgG)-like T-cell engaging (TCE) antibody targeting
the tumor-associated antigen (TAA) CD20 and the T-cell surface antigens CD3 and CD8,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-CD20/anti-CD3/anti-CD8 trispecific antibody AZD5492 targets and binds to CD20
on CD20-expressing tumor B-cell, and the CD3 and CD8 antigens on CD8-positive T-lymphocytes.
The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response
against CD20-expressing tumor cells. CD20, a B-cell-specific cell surface antigen,
is overexpressed in B-cell lineage malignancies.;
Molecule name : AZD-5492; AZD 5492;
Origin ID : C210037;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
