Preferred Label : Anti-CD3 x Anti-CD20 Bispecific Antibody-Armed Activated T Cells;
NCIt synonyms : Anti-CD3 x CD20Bi-Armed ATC;
NCIt definition : Autologous activated T cells that have been coated with bispecific antibodies (BiAb),
with potential antineoplastic and immunomodulating activities. In vitro, T cells are
activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and low-dose
interleukin 2 (Il-2) for 6-14 days and then armed with anti-CD3 x anti-CD20 bispecific
antibody (CD20Bi). Upon administration, anti-CD3 x anti-CD20 bispecific antibody-armed
activated T cells (AATC) attach to CD3-expressing T cells and CD20-expressing tumor
cells, selectively cross-linking T cells and tumor cells. This may result in the recruitment
and activation of cytotoxic T lymphocyte (CTLs), CTL-mediated specific tumor cell
lysis, and the secretion of antitumor cytokines and chemokines. CD20, a cell surface
phosphoprotein, is found on normal B cells and most B-cell tumors.;
NCI Metathesaurus CUI : CL376176;
Origin ID : C95751;
UMLS CUI : C2987399;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
