NCIt definition : A bispecific antibody and novel T cell engager1 (nTCE) targeting both the tumor-associated
antigen (TAA) CD20 and the CD3, a T-cell surface antigen, with potential immunomodulating
and antineoplastic activities. Upon administration, anti-cd20/anti-cd3 bispecific
antibody CM355 binds to both T-cells and CD20-expressing B-lineage tumor cells. The
resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response
against the CD20-expressing tumor B-cells. CD20 is exclusively expressed on B-cells
during most stages of B-cell development and is often overexpressed in B-cell malignancies.;
Semantic type(s)