" /> Ocaratuzumab - CISMeF





Preferred Label : Ocaratuzumab;

NCIt synonyms : monoclonal antibody, CD20; MoAb CD20; Anti-CD20 Monoclonal Antibody AME-133v; Monoclonal Antibody CD20;

NCIt definition : An Fc-engineered monoclonal antibody directed against human CD20 with potential antineoplastic activity. Ocaratuzumab specifically binds to CD20 antigen (B1), preventing mitogen-induced B-cell proliferation; inhibiting B-cell differentiation; and promoting antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis of B cells expressing CD20. The Fc portion of this monoclonal antibody has been engineered to possess a higher binding affinity for variant Fc receptors on T helper cells, resulting in an augmentation of the anti-tumor immune response. Because of Fc engineering, this agent may be significantly more potent than rituximab in inducing B cell-directed ADCC. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development.;

UNII : NTY9893GD0;

CAS number : 1169956-08-4;

Molecule name : LY 2469298; AME-133v;

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05/07/2025


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