Preferred Label : Prulacabtagene Leucel;
NCIt synonyms : Allogeneic Anti-CD20 CAR-engineered Gamma Delta T Cells ADI-001; Allogeneic Anti-CD20-CAR Gamma Delta T-lymphocytes ADI-001; Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001;
NCIt definition : A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain
and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster
of differentiation 20), with potential immunomodulating and antineoplastic activities.
Upon administration, prulacabtagene leucel specifically target and bind to tumor cells
expressing CD20. This induces secretion of pro-inflammatory cytokines and results
in the lysis of CD20-expressing tumor cells. Gamma delta T-lymphocytes play a key
role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The CD20
antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell
surface antigen overexpressed in B-cell lineage malignancies.;
UNII : PA43J5W22U;
Molecule name : ADI 001; ADI-001;
NCI Metathesaurus CUI : CL1648148;
Origin ID : C178424;
UMLS CUI : C5555023;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
