Preferred Label : Autologous Anti-CD19/Anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFRt -expressing Tn/mem Cells;
NCIt synonyms : Autologous Anti-CD19/20 CAR-CD28-4-1BB-CD3zeta-EGFRt -expressing Naive and Memory
T-lymphocytes; Autologous Anti-CD19/20 Bispecific CAR-CD28-BBz-EGFRt -expressing Tn/mem Cells;
NCIt definition : A preparation of genetically modified autologous naive/memory T-cells (Tn/mem), that
have been transduced with a self-inactivating (SIN) lentiviral vector to express a
bispecific chimeric antigen receptor (CAR) consisting of a single chain variable fragment
(scFv) of anti-CD19, derived from the anti-CD19 monoclonal antibody FMC63, in tandem
with an anti-CD20 scFv, derived from the anti-CD20 monoclonal antibody Leu16, and
fused to the hinge domain of human immunoglobulin (Ig) G4, the transmembrane domain
of human CD28, and the cytoplasmic signaling domains of 4-1BB (CD137) and the T-cell
antigen receptor complex zeta chain (CD3-zeta) (BBz), and linked via the T2A sequence
to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential
immunostimulating and antineoplastic activities. Upon transfusion, autologous anti-CD19/anti-CD20-CAR-CD28-4-1BB-CD3zeta-EGFR
-expressing Tn/mem cells recognize and induce selective toxicity in CD19/CD20-expressing
tumor cells, resulting in tumor cell lysis. Both CD19 and CD20 are B-cell-specific
cell surface antigens overexpressed in B-cell lineage malignancies. Devoid of both
ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo
detection of the administered T-cells and can promote elimination of those cells upon
a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response.;
NCI Metathesaurus CUI : CL969754;
Origin ID : C160777;
UMLS CUI : C5205544;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
