Preferred Label : Allogeneic Rituximab Conjugated Gamma Delta T-cells ACE1831;
NCIt synonyms : Allogeneic Rituximab-conjugated Gamma Delta T-cells ACE1831; Allogeneic Rituximab Armed Gamma Delta T-cells ACE1831;
NCIt definition : An off-the-shelf preparation of a subset of allogeneic T-lymphocytes that express
only gamma chain and delta chain T-cell receptors (TCRs) conjugated to a DNA linker,
attached via DNA hybridization to rituximab conjugated to another DNA linker, with
potential immunomodulating and antineoplastic activities. Upon administration of the
allogeneic rituximab conjugated gamma delta T-cells ACE1831, rituximab targets and
binds to CD20 expressed on tumor cells. The gamma delta T-cells secrete interferon-gamma
(IFN-g) and exert direct killing of the CD20-expressing tumor cells. In addition,
these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response
against CD20-expressing tumor cells. Gamma delta T-lymphocytes play a key role in
the activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect. The CD20 antigen,
a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface
antigen overexpressed in B-cell lineage malignancies.;
Molecule name : ACE-1831; ACE 1831;
NCI Metathesaurus CUI : CL1914181;
Origin ID : C198411;
UMLS CUI : C5787069;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
