Preferred Label : Anti-CD20-engineered Toxin Body MT-3724;
NCIt related terms : MT-3724;
NCIt definition : An engineered toxin body (ETB) composed of the single-chain variable fragment (ScFv)
from an antibody targeting CD20 that is linked to a modified form of the ribosome-inactivating
alpha subunit of Shiga-like toxin 1 (Shiga-like Toxin-1 A or SLT-1A), with antineoplastic
activity. Upon administration, the ScFv moiety of anti-CD20-engineered toxin body
MT-3724 targets and binds to the CD20 antigen expressed on tumor cells. Upon internalization,
the SLT-1A moiety is released and acts as an N-glycosidase, which binds to and cleaves
an adenine nucleobase in the 28S RNA component of the 60S subunit of ribosomes and
prevents ribosome activity. This inhibits protein synthesis and eventually leads to
apoptosis of CD20-expressing tumor cells. CD20, a B-cell specific transmembrane protein
and tumor-associated antigen (TAA), is expressed during most stages of B-cell development
and is often overexpressed in B-cell malignancies.;
UNII : R23ZRN6GWR;
Molecule name : MT-3724;
Origin ID : C120546;
UMLS CUI : C4053580;
Semantic type(s)
- concept_is_in_subset
- has_target
