Preferred Label : Allogeneic Anti-CD20/CD22 Universal CAR-expressing T-lymphocytes UCART20x22;
NCIt synonyms : Allogeneic Anti-CD20/CD22 Universal CAR-expressing T-cells UCART20x22; Allogeneic Anti-CD20/CD22 Universal CAR T Cells UCART20x22; CAR-T Cells UCART20x22; Allogeneic Anti-CD20/CD22 Universal CAR-T Cells UCART20x22;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like
effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified
to express chimeric antigen receptors (CARs) specific for the tumor-associated antigens
(TAAs) cluster of differentiation 20 (CD20) and CD22, with potential immunostimulating
and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha
chain (TRAC) and CD52 genes are inactivated. Upon administration, the allogeneic anti-CD20/CD22
universal CAR-expressing T-lymphocytes UCART20x22 specifically recognize and induce
selective toxicity in CD20- and CD22-expressing tumor cells. CD20 and CD22 are overexpressed
in certain hematologic malignancies. Inactivation of the CD52 gene makes the CAR-T
cells UCART20x22 resistant to anti-CD52 monoclonal antibody treatment that is used
during preconditioning regimen to enhance the expansion and persistence of the CAR-T
cells. The knockout of TRAC eliminates TCR expression and is intended to abrogate
the potential induction of graft-versus-host disease (GvHD) by the CAR-T cells.;
Molecule name : UCART-20x22; UCART 20x22;
NCI Metathesaurus CUI : CL1913082;
Origin ID : C193468;
UMLS CUI : C5785777;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
