NCIt synonyms : Anti-CD20 x Anti-CD3 Bispecific Monoclonal Antibody REGN1979; WHO 11035;
NCIt definition : A bispecific, human monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3
monoclonal antibody REGN1979 contains two antigen-recognition sites: one for human
CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen
that is exclusively expressed on B-cells during most stages of B-cell development
and is often overexpressed in B-cell malignancies. Upon administration, odronextamab
binds to both T-cells and CD20-expressing tumor B-cells, which cross-links the T-cells
to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against
CD20-expressing tumor B-cells.;
UNII : 8R5CM46UIO;
CAS number : 1801338-64-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1801338-64-6
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Semantic type(s)