Preferred Label : Eramkafusp Alfa;
NCIt synonyms : Anti-CD20 Monoclonal Antibody-IFN-a Fusion Protein IGN002; Anti-CD20 Monoclonal Antibody-Interferon-alpha Fusion Protein IGN002;
NCIt definition : A humanized monoclonal antibody directed against the human B-cell-specific cell surface
antigen CD20 and fused to the recombinant cytokine, interferon-alpha (IFN-a), with
potential antineoplastic and immunomodulating activities. Upon administration of eramkafusp
alfa, the antibody moiety specifically targets and binds to CD20. In turn, the IFN-a
moiety binds to the IFN receptor, and activates IFN-mediated signal transduction,
which induces the transcription and translation of genes whose protein products mediate
anticancer effects. This results in the induction of both G2 cell cycle arrest and
apoptosis in CD20-expressing tumor cells. In addition, IGN002 causes the induction
of complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity
(ADCC) against CD20-expressing B-cells, which leads to B-cell apoptosis and the inhibition
of tumor cell proliferation. CD20, a non-glycosylated cell surface phosphoprotein
that is exclusively expressed on B-cells during most stages of B-cell development,
is often overexpressed in B-cell malignancies.;
UNII : N7FO1V18PR;
CAS number : 2388499-82-7;
Molecule name : IGN002;
NCI Metathesaurus CUI : CL498279;
Origin ID : C123915;
UMLS CUI : C5667149;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
