Preferred Label : Allogeneic Anti-CD20-CAR T-cells PBCAR20A;
NCIt synonyms : Allogeneic Anti-CD20 CAR T-lymphocytes PBCAR20A;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS), T-lymphocytes, derived from healthy
donors, that have been genetically modified using a proprietary synthetic endonuclease-based
system to express a chimeric antigen receptor (CAR) targeting the tumor-associated
antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating
and antineoplastic activities. Upon administration, allogeneic anti-CD20-CAR T-cells
PBCAR20A specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen,
a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface
antigen expressed in B-cell lineage malignancies.;
Molecule name : PBCAR 20A; PBCAR-20A;
NCI Metathesaurus CUI : CL972895;
Origin ID : C168570;
UMLS CUI : C5238954;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
