Preferred Label : Anti-CD19/CD20 Bicistronic CAR T-cells;
NCIt synonyms : CD19x20 Bicistronic CAR T-cells; CD19/CD20 Bicistronic CAR-transduced T Cells;
NCIt definition : A preparation of T-lymphocytes that have been transduced with a bicistronic vector
encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated
antigen (TAA) CD19 and the other one against the TAA CD20, with potential immunomodulating
and antineoplastic activities. Upon administration, the anti-CD19/CD20 bicistronic
CAR T-cells target, bind to and induce selective toxicity in tumor cells expressing
CD19 and/or CD20. CD19 and CD20, both transmembrane phosphoglycoproteins expressed
on the surface of cells in the B lineage, are often overexpressed on malignant B-cells.
By simultaneously targeting two B-cell antigens using two different CARs, this preparation
may minimize relapse due to single antigen loss in patients with B-cell malignancies.;
NCI Metathesaurus CUI : CL1906325;
Origin ID : C198878;
UMLS CUI : C5855198;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
