NCIt synonyms : Autologous CD19/CD20-targeting CAR T-cells EXP039; Autologous Anti-CD19/Anti-CD20 CAR T Cells EXP039; Autologous Anti-CD19/CD20 CAR-T Cells C-CAR039;
NCIt definition : A preparation of autologous T-lymphocytes engineered to express a second-generation
chimeric antigen receptor (CAR) specific for the two tumor-associated antigens (TAAs)
cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and
antineoplastic activities. Upon administration, prizloncabtagene autoleucel targets
and binds to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity
in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell
surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19
and CD20 may prevent tumor cell antigen escape and relapse.;
UNII : 35X9XB2HBG;
Molecule name : EXP-039; EXP 039; C CAR039; C-CAR039;