CD20-targeted Polypeptide TRU-015

Preferred Label : CD20-targeted Polypeptide TRU-015;

NCIt synonyms : CD20-targeted Compound TRU-015;

NCIt related terms : TRU-015;

NCIt definition : A proprietary antibody-based single-chain polypeptide with B cell-depleting activity. Significantly smaller than a whole antibody, CD20-targeted polypeptide TRU-015 binds specifically to the B cell-specific cell surface antigen CD20 with full immunoglobulin Fv fragment-type target binding activity and full immunoglobulin Fc fragment-type effector function. This agent transiently depletes CD20-bearing B cells by inducing B cell -directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) and B cell apoptosis.;

UNII : T0N62K2M2Y;

CAS number : 1169717-01-4;

Molecule name : TRU-015;

NCI Metathesaurus CUI : CL375944;

Details

Origin ID

C70797;

UMLS CUI

C2347249;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- B-Lymphocyte Antigen CD20 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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