Ublituximab - CISMeF

Preferred Label : Ublituximab;

NCIt definition : A chimeric recombinant IgG1 monoclonal antibody directed against human CD20 with potential antineoplastic activity. Ublituximab specifically binds to the B cell-specific cell surface antigen CD20, thereby potentially inducing a B cell-directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) against CD20-expressing B cells, leading to B cell apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development and is often overexpressed in B-cell malignancies. Ublituximab has a specific glycosylation profile, with a low fucose content, that may enhance its ADCC response against malignant B cells.;

UNII : U59UGK3IPC;

CAS number : 1174014-05-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1174014-05-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LFB-R603; TG-20; TGTX-1101; TG-1101;

Codes from synonyms : 520;

Details

Origin ID

C91078;

UMLS CUI

C4083151;

Automatic exact mappings (from CISMeF team)
- LFB-R603 [MeSH concept]
CISMeF manual mappings
- ublituximab [MeSH concept]
Currated CISMeF NLP mapping
- ublituximab [MeSH Supplementary Concept]
- ublituximab [ATC Code]
See also inter- (CISMeF)
- LFB-R603 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ublituximab [MeSH Supplementary Concept]
- ublituximab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD20 [NCIt concept]

Keyword's position in hierarchy(ies) :

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