Preferred Label : Allogeneic CD19/CD20-specific CAR-T Cells P-CD19CD20-ALLO1;
NCIt synonyms : Allogeneic T Stem Cell Memory CAR-T Cells P-CD19CD20-ALLO1; Allogeneic Anti-CD19/Anti-CD20 CAR T Cells P-CD19CD20-ALLO1; Allogeneic Tscm CAR-T Cells P-CD19CD20-ALLO1;
NCIt definition : An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily
stem cell memory T-cells (Tscm) that have been genetically modified to express two
chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) CD19
and CD20, with potential immunostimulating and antineoplastic activities. Upon administration,
allogeneic CD19/CD20-specific CAR-T cells P-CD19CD20-ALLO1 specifically recognize
and induce selective toxicity in CD19- and/or CD20-expressing tumor cells. Both CD19
and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage
malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and
relapse.;
Molecule name : P-CD19CD20-ALLO-1; P-CD19CD20-ALLO 1;
NCI Metathesaurus CUI : CL1920679;
Origin ID : C201791;
UMLS CUI : C5907928;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
