Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1

Preferred Label : Autologous Anti-CD20 CAR Transduced CD4/CD8 Enriched T-cells MB-CART20.1;

NCIt synonyms : CD20-targeting CAR T Cells MB-CART20.1; MB-CART20.1; Autologous CD20-targeted CAR-transduced CD4/CD8 Enriched T Cells MB-CART20.1; Anti-CD20 CAR T Cells MB-CART20.1;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), and CD4/CD8 enriched, with potential immunostimulating and antineoplastic activities. Upon administration, MB-CART20.1 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies and certain melanoma cell subpopulations.;

NCI Metathesaurus CUI : CL1406185;

Details

Origin ID

C172063;

UMLS CUI

C5419440;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD20 [NCIt concept]

Keyword's position in hierarchy(ies) :

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