Preferred Label : Anti-CD20/CD3 Bispecific Antibody EX103;
NCIt synonyms : CD3 x CD20 BiAb EX103; CD20 x CD3 Bispecific Antibody EX103; Anti-CD20/Anti-CD3 Bispecific Antibody EX103;
NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) CD20 and the
T-cell surface antigen CD3, with potential immunomodulating and antineoplastic activities.
Upon administration, anti-CD20/CD3 bispecific antibody EX103 binds to both CD3 on
T-cells and CD20 on CD20-expressing B-lineage tumor cells. The resulting cross-linkage
may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing
tumor B cells. CD20 is exclusively expressed on B cells during most stages of B-cell
development and is often overexpressed in B-cell malignancies.;
Molecule name : EX-103; EX 103;
Origin ID : C201651;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
