NCIt definition : A recombinant humanized monoclonal antibody directed against human CD20 with potential
antineoplastic activity. Upon intravenous administration, anti-CD20 monoclonal antibody
B001 specifically binds to CD20 on the surfaces of B-cells. Although the exact mechanisms
through which B001 exert its effects have not been elucidated, B001 may induce a B-cell
directed cell-mediated immune response against CD20-expressing B-cells and/or prevent
CD20-medaited signaling. This induces tumor cell apoptosis and inhibits proliferation.
CD20 is a non-glycosylated cell surface phosphoprotein which is exclusively expressed
on B-cells during most stages of B-cell development and which is often overexpressed
in B-cell malignancies.;
Semantic type(s)