Preferred Label : Anti-CD20 Antibody-drug Conjugate TRS005;
NCIt synonyms : Anti-CD20 ADC TRS005; Anti-CD20/MMAE ADC TRS005; ADC TRS005;
NCIt definition : An antibody-drug conjugate (ADC) composed of an anti-CD20 monoclonal antibody conjugated
via a valine-citrulline linker to monomethyl auristatin E (MMAE), an auristatin derivative
and a potent microtubule disrupting agent, with potential antineoplastic activity.
Upon administration, the monoclonal antibody moiety of anti-CD20 ADC TRS005 targets
and binds to CD20 on the surfaces of tumor B-cells. Upon internalization and cleavage,
MMAE is released. MMAE binds to tubulin and inhibits its polymerization, resulting
in G2/M checkpoint arrest and apoptosis in CD20-expressing tumor cells. CD20 is a
non-glycosylated cell surface phosphoprotein which is exclusively expressed on B-cells
during most stages of B-cell development. It is often overexpressed in B-cell malignancies.;
Molecule name : TRS 005; TRS-005;
NCI Metathesaurus CUI : CL1792748;
Origin ID : C188178;
UMLS CUI : C5706460;
Semantic type(s)
- concept_is_in_subset
- has_target
