NCIt definition : A third-generation, humanized monoclonal antibody directed against human CD20 with
potential antineoplastic activity. Anti-CD20 monoclonal antibody PRO131921 specifically
binds to the B cell-specific cell surface antigen CD20. This may result in the induction
of a B cell-directed complement dependent cytotoxicity (CDC) and antibody-dependent
cell-mediated cytotoxicity (ADCC) against CD20-expressing B cells leading to B cell
apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein which is exclusively
expressed on B cells during most stages of B cell development and which is often overexpressed
in B-cell malignancies.;