Tositumomab - CISMeF

Preferred Label : Tositumomab;

NCIt synonyms : Anti-CD20 Antibody; Monoclonal Antibody Anti-B1; anti-B1; MoAb Anti-B1;

NCIt definition : A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells. Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity. (NCI04);

Alternative definition : NCI-GLOSS: A monoclonal antibody that is used in the treatment of certain types of non-Hodgkin lymphoma. When tositumomab and iodine I 131 tositumomab (a form of tositumomab that has been chemically changed by adding radioactive iodine) are given together, the combination is called the Bexxar regimen.;

UNII : 0343IGH41U;

CAS number : 192391-48-3;

Codes from synonyms : CDR0000367410;

Details

Origin ID

C2543;

UMLS CUI

C0879399;

Currated CISMeF NLP mapping
- Tositumomab (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing tositumomab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tositumomab (medicinal product) [SNOMED CT concept]
- Tositumomab (substance) [SNOMED CT concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD20 [NCIt concept]
is_component_of_chemotherapy_regimen
- Tositumomab and Iodine I 131 Tositumomab [NCIt concept]

Keyword's position in hierarchy(ies) :

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