Iodine I 131 Tositumomab

Preferred Label : Iodine I 131 Tositumomab;

NCIt synonyms : Iodine-131 Tositumomab; 131-I-Anti-B1 Monoclonal Antibody; I 131 Tositumomab; Iodine-131 Anti-CD20 Monoclonal Antibody; Iodine I 131 MOAB Anti-B1; I 131 Monoclonal Antibody Anti-B1; Iodine-131 Anti-B1 Antibody; Iodine I 131 Monoclonal Antibody Anti-B1; I131-MOAB-B1;

NCIt related terms : TOSITUMOMAB I-131; Tositumomab and I-131;

NCIt definition : A monoclonal antibody directed against the CD20 protein expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope iodine I 131 with potential antineoplastic activity. Iodine I 131 tositumomab binds to and selectively delivers cyctotoxic radiation to CD20-expressing B-lymphocytes, thereby minimizing systemic radiotoxicity.;

Alternative definition : NCI-GLOSS: A monoclonal antibody (tositumomab) that has been chemically changed by adding radioactive iodine, and that is used in the treatment of certain types of non-Hodgkin lymphoma. It belongs to the family of drugs called radioconjugated monoclonal antibodies. When iodine I 131 tositumomab and tositumomab are given together, the combination is called the Bexxar regimen.;

UNII : K1KT5M40JC;

CAS number : 192391-48-3;

Drug name : Bexxar;

NSC code : 715813;

Codes from synonyms : CDR0000367409; 506;

Details

Origin ID

C2444;

UMLS CUI

C0768182;

CISMeF manual mappings
- I-131 tositumomab [Radlex concept]
Currated CISMeF NLP mapping
- tositumomab I-131 [MeSH concept]
- tositumomab I-131 [MeSH Supplementary Concept]
- tositumomab/iodine (131i) tositumomab [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- I-131 tositumomab [Radlex concept]
- tositumomab I-131 [MeSH Supplementary Concept]
- tositumomab I-131 [MeSH concept]
- tositumomab/iodine (131i) tositumomab [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD20 [NCIt concept]
is_component_of_chemotherapy_regimen
- Cyclophosphamide/Doxorubicin/Iodine I 131 Tositumomab/Prednisone/Vincristine [NCIt concept]
- Cyclophosphamide/Etoposide/Iodine I 131 Tositumomab [NCIt concept]
- Cyclophosphamide/Etoposide/iodine I 131 Monoclonal Antibody Anti-B1 [NCIt concept]
- Tositumomab and Iodine I 131 Tositumomab [NCIt concept]

Keyword's position in hierarchy(ies) :

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