Preferred Label : DI-Leu16-IL2 Immunocytokine;
NCIt synonyms : De-Immunized Anti-CD20-IL-2 Immunocytokine DI-Leu16-IL-2; DI-Leu16-IL-2; De-Immunized DI-Leu16-IL2 Immunocytokine;
NCIt related terms : DI-LEU16-IL2;
NCIt definition : A recombinant fusion protein consisting of de-immunized and humanized anti-CD20 monoclonal
antibody Leu16 fused to human cytokine interleukin-2 (IL2) with potential antineoplastic
activity. The antibody moiety of DI-Leu16-IL2 immunocytokine binds to tumor cells
expressing the CD20 antigen, which may result in an antibody-dependent cell-mediated
cytotoxicity (ADCC) towards CD20-expressing tumor cells; the localized IL2 moiety
of this fusion protein may stimulate natural killer (NK) and T-lymphocyte mediated
immune responses, enhancing the ADCC response. De-immunization involves the modification
of potential helper T cell epitopes that bind to MHC class II molecules; humanization
involves combining recombinant murine variable (V) regions with human immunoglobulin
light and heavy chain constant regions. CD20 antigen, a hydrophobic transmembrane
protein located on normal pre-B and mature B lymphocytes, is overexpressed by various
cancer cell types.;
UNII : 8PQK3QPW4P;
NCI Metathesaurus CUI : CL387463;
Origin ID : C78451;
UMLS CUI : C2699565;
Semantic type(s)
- concept_is_in_subset
- has_target
