NCIt definition : An immunoconjugate of the monoclonal antibody ibritumomab conjugated with the linker-chelator
tiuxetan, a high affinity, conformationally restricted chelation site for radioisotopes.
When bound to indium In 111 or yttrium Y 90, ibritumomab tiuxetan, targeting the CD20
antigen on B cell surfaces, specifically delivers a potentially cytotoxic dose of
radiation to B lymphocytes. Ibritumomab is a murine IgG1 kappa monoclonal antibody
directed against the CD20 antigen, which is found on the surface of normal and malignant
B lymphocytes.;
Alternative definition : NCI-GLOSS: A monoclonal antibody that is used to treat certain types of B-cell non-Hodgkin
lymphoma and is being studied in the treatment and detection of other types of B-cell
tumors. Monoclonal antibodies are made in the laboratory and can locate and bind to
substances in the body, including cancer cells. Ibritumomab binds to the protein called
CD20, which is found on B cells. It is linked to the compound tiuxetan. This allows
certain radioisotopes to be attached before it is given to a patient. It is a type
of monoclonal antibody-chelator conjugate.;
UNII : 4Q52C550XK;
CAS number : 206181-63-7;
Drug name : Zevalin;
Molecule name : IDEC-129; IDEC-2B8;
Chemical formula : C23H32N5O10S;
Codes from synonyms : CDR0000579649; CDR0000574728; 262;
Automatic exact mappings (from CISMeF team)