Preferred Label : Anti-CD20/Anti-CD22 CAR T-cells;
NCIt synonyms : CD20/CD22 Dual Targeted CAR T-cells; CD20/CD22-targeted CAR T-cells;
NCIt definition : A preparation of human T-lymphocytes engineered to express chimeric antigen receptors
(CARs) specific for the tumor-associated antigens (TAAs) cluster of differentiation
20 (CD20) and CD22, with potential immunostimulating and antineoplastic activities.
Upon administration, the anti-CD20/anti-CD22 CAR T-cells target and bind to both CD20
and CD22 expressed on the surface of tumor cells. This induces selective toxicity
in tumor cells expressing these TAAs. CD20 and CD22 are overexpressed in certain hematologic
malignancies.;
NCI Metathesaurus CUI : CL1413417;
Origin ID : C175977;
UMLS CUI : C5446899;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
