Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes - CISMeF
Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T LymphocytesNCIt concept
Preferred Label : Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes;
NCIt synonyms : Anti-CD22-CAR m971-BBz Cells;
NCIt definition : Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding
a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of an anti-CD22
single chain variable fragment (scFv) derived from the monoclonal antibody (moAb)
971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain
of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic
activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with CD22-positive
cancer are transduced with this lentiviral vector that encodes the CAR gene specific
for CD22. After expansion in culture and reintroduction into the patient, the anti-CD22-CAR
m971-BBz lentiviral vector-transduced autologous T-lymphocytes express anti-CD22-CAR
on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently,
CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane
phosphoglycoprotein, is expressed on malignant B-cells. m971 binds to a membrane proximal
epitope on CD22 and has a higher binding affinity compared to other anti-CD22 moAb.;