Preferred Label : Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins;
NCIt synonyms : Deglycosylated Ricin A Chain-Conjugated Anti-CD19 Anti-CD22 Immunotoxins;
NCIt definition : A combination preparation of 1:1 mixture of two immunotoxins, HD37-dgA and RFB4-dgA,
with potential antineoplastic activity. Both anti-CD19 IgG monoclonal antibody HD37
and anti-CD22 IgG monoclonal antibody RFB4 are attached to a single deglycosylated
ricin A chain (dgA) via N-succinimidyl-oxycarbonyl-alpha-methyl-alpha-(2-pyridyldithio)
toluene (SMPT) linker. CD19 and CD22 molecules are cell suface antigens present on
the majority of B acute lymphoblastic leukemia cells. This combination agent is able
to specifically recognize and bind to CD19 and CD22 expressing tumor cells, thereby
targeting the delivery of the cytotoxic ricin A chain to leukemia cells expressing
these antigens. Ricin A chain is toxic to ribosomal activity and protein synthesis,
and inhibits cell growth.;
Drug name : Combotox;
Origin ID : C67061;
UMLS CUI : C1880270;
Semantic type(s)
- concept_is_in_subset
- has_target
