Preferred Label : Anti-CD22 CAR-expressing T Lymphocytes;
NCIt synonyms : CD22 CAR-T; Anti-CD22 CAR-expressing T-cells;
NCIt definition : A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding
a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or
more binding domains targeting the tumor-associated antigen (TAA) CD22 and fused to
one or more co-stimulatory, TCR-signaling domains, with potential immunostimulating
and antineoplastic activities. Upon administration, the anti-CD22 CAR-expressing T-lymphocytes,
express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor
cell surfaces. Subsequently, CD22-expressing B-cells are lysed. CD22, a B-lineage-restricted,
transmembrane phosphoglycoprotein, is expressed on malignant B-cells.;
NCI Metathesaurus CUI : CL507942;
Origin ID : C128556;
UMLS CUI : C4289974;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
