Preferred Label : Allogeneic Anti-CD19/CD22 CAR-BBz T-cells;
NCIt synonyms : Allogeneic CD19/CD22-CAR T Cells; Allogeneic Anti-CD19/Anti-CD22 CAR T Cells; Allogeneic CD19/CD22-BBz CAR T Cells; Allogeneic Anti-CD19/CD22 CAR T-cells; Allogeneic Anti-CD19/CD22 CAR-T Cells;
NCIt definition : A preparation of allogeneic T-lymphocytes that have been transduced with a bivalent
lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the two tumor-associated
antigens (TAAs) CD19 and CD22, linked to the co-stimulatory domain 4-1BB (CD137) coupled
to the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential
immunostimulating and antineoplastic activities. Upon administration, the allogeneic
anti-CD19/CD22 CAR-BBz T-cells bind to and induce selective toxicity in tumor cells
expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed
on the surface of cells in the B lineage, are often overexpressed on malignant B-cells.
By simultaneously targeting two B-cell antigens, this preparation may minimize relapse
due to single antigen loss in patients with B-cell malignancies.;
NCI Metathesaurus CUI : CL1798441;
Origin ID : C189702;
UMLS CUI : C5708695;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
