Preferred Label : Autologous Anti-CD19/CD22 CAR T-cells AUTO3;
NCIt synonyms : Anti-CD19/CD22 CAR Autologous T-lymphocytes AUTO3;
NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a bicistronic
retroviral vector encoding both an anti-CD19 chimeric antigen receptor (CAR) fused
to OX40 co-stimulatory domain and an anti-CD22 CAR linked to the intracellular signaling
domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247;
CD3zeta), optimized with a novel pentameric spacer derived from the collagen oligomeric
matrix protein (COMP), with potential antineoplastic activity. Upon administration,
the autologous anti-CD19/CD22 CAR T-cells AUTO3 bind to and induce selective toxicity
in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins
expressed on the surface of cells in the B lineage, are often overexpressed on malignant
B-cells. By simultaneously targeting two B-cell antigens, this preparation may minimize
relapse due to single antigen loss in patients with B-cell malignancies.;
Molecule name : AUTO-3; AUTO 3;
NCI Metathesaurus CUI : CL971066;
Origin ID : C162620;
UMLS CUI : C5206698;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
https://minerva-ebp.be/FR/Article/2363
2024
Belgium
critical appraisal or critical reading
disease
disease, nos
Illinois
Useful
tretinoin
fatty acids, Omega-3
Autologous Anti-CD19/CD22 CAR T-cells AUTO3
Immune
vitamin D
Disease or Disorder
vitamin d, nos
Interleukin
fatty acid, nos
fatty acids
immune system diseases
What Month is it
Vitamin D Measurement
Ergocalciferol
Israel
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