Preferred Label : CD19x22 Bicistronic CAR T-cells;
NCIt synonyms : CD19xCD22 Bicistronic CAR T-cells; CD19x22 Bicistronic CAR T-lymphocytes; Anti-CD19/CD22 Bicistronic CAR T-cells; CD19/CD22 Bicistronic CAR-transduced T Cells;
NCIt definition : A preparation of T-lymphocytes that have that have been transduced with a bicistronic
vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated
antigen (TAA) CD19 and the other one against the TAA CD22, with potential immunomodulating
and antineoplastic activities. Upon administration, the CD19x22 bicistronic CAR T-cells
target, bind to and induce selective toxicity in tumor cells expressing CD19 and CD22.
CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of
cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously
targeting two B-cell antigens using two different CARs, this preparation may minimize
relapse due to single antigen loss in patients with B-cell malignancies.;
NCI Metathesaurus CUI : CL1771364;
Origin ID : C183133;
UMLS CUI : C5668164;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
