Preferred Label : Allogeneic Hypoimmune Anti-CD22 CAR T-cells SC262;
NCIt synonyms : Hypoimmune-modified CD22-directed Allogeneic CAR-T Cells SC262; Allogeneic Hypoimmune CD22-directed CAR T-cells SC262; Allogeneic Anti-CD22 CAR T Cells SC262; Allogeneic HIP Anti-CD22 CAR-T Cells SC262;
NCIt definition : A preparation of human allogeneic CD4 and CD8 T-lymphocytes transduced with a chimeric
antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD22, and ex
vivo modified to disrupt the expression of major histocompatibility (MHC) class I
and MHC class II molecules and to express CD47, with potential immunomodulating and
antineoplastic activities. Upon introduction into the patient, the allogeneic hypoimmune
anti-CD22 CAR T-cells SC262 recognize and bind to CD22-expressing tumor cells. This
may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD22-positive
tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed
on malignant B-cells. The disruption of MHC class I and MHC class II molecules and
the expression of CD47 prevent both innate and adaptive immune responses against the
allogeneic CAR T-cells, thereby increasing the persistence of the CAR T-cells.;
Molecule name : SC 262; SC-262;
NCI Metathesaurus CUI : CL1928814;
Origin ID : C206707;
concept_is_in_subset
- has_target
