" /> L-Selectin - CISMeF





Preferred Label : L-Selectin;

NCIt synonyms : Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; SELL; Selectin L; CD62 Antigen-Like Family Member L; LAM-1; Leukocyte Surface Antigen Leu-8; TQ1; gp90-MEL; CD62L; LECAM1; Selectin-L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen Ligand; Leukocyte Adhesion Molecule 1; CD62L Antigen; Pln Homing Receptor;

NCIt definition : L-selectin (372 aa, 42 kDa) is encoded by the human SELL gene. This protein plays a role in leukocyte adhesion and rolling.;

NCIt note : L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units. L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation. A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain. PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.; Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.;

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16/05/2024


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