Myelin Protein Zero-Like 1

Preferred Label : Myelin Protein Zero-Like 1;

NCIt synonyms : MPZL1; PZR; Protein Zero-Related; Myelin Protein Zero-Like-1 Protein;

NCIt definition : Myelin protein zero-like protein 1 (269 aa, 29 kDa) is encoded by the human MPZL1 gene. This protein is involved in both ligand binding and signal transduction.;

NCIt note : Widely expressed (highest in heart, placenta, kidney, and pancreas) by human MPZL1 Gene (Ig Superfamily), 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein contains an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src.;

Details

Origin ID

C33951;

UMLS CUI

C1334837;

OMIM relation
- Myelin protein zero-like 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MPZL1 protein, human [MeSH concept]
- MPZL1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- MPZL1 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Focal Adhesion [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- ITIM [NCIt concept]
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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